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IAP proteins are attractive cancer therapeutic targets. SM-406 is a potent and orally bioavailable antagonist of the IAPs. PK studies of SM-406 in male SD rats, beagle dogs and NHP were performed by Medicilon

2023-07-17
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Apoptosis is a cellular process critical to the normal development and homeostasis of multicellular organisms. 

The inhibitor of apoptosis proteins (IAPs) are a class of key apoptosis regulators. IAP proteins are attractive cancer therapeutic targets. SM-406 (compound 2) is a potent and orally bioavailable antagonist of the IAPs.

Pharmacokinetic (PK) studies of SM-406 (compound 2) in male Sprague Dawley rats, beagle dogs and cynomolgus monkeys (non-human primates) were performed by the Division of Pharmacokinetics and Metabolism, Medicilon.

SM-406 (compound 2) has an excellent PK profile and good oral bioavailability in each of these four species.

37.jpgReference:

Qian Cai, et al. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem. 2011 Apr 28;54(8):2714-26. doi: 10.1021/jm101505d. 

cancer-therapeuticPharmacokineticSD-ratsbeagle-dogscynomolgus-monkeysnon-human-primatesNHP
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